منابع مشابه
Insulin fails to enhance mTOR phosphorylation, mitochondrial protein synthesis, and ATP production in human skeletal muscle without amino acid replacement.
Systemic insulin administration causes hypoaminoacidemia by inhibiting protein degradation, which may in turn inhibit muscle protein synthesis (PS). Insulin enhances muscle mitochondrial PS and ATP production when hypoaminoacidemia is prevented by exogenous amino acid (AA) replacement. We determined whether insulin would stimulate mitochondrial PS and ATP production in the absence of AA replace...
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Slr: We have previously used the hexokinase-catalyzed conversion of glucose to glucose G-phosphate to illustrate the practicality of ATP regeneration in enzyme-catalyzed organic synthesis.2 The equilibrium constant for phosphate transfer from ATP to glucose is large (K = 1.5 X 102 at pH 6.0),3 and this reaction goes to completion. ATP is, however, only a moderately strong biological phosphoryla...
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Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel, an ATP binding cassette (ABC) transporter. CFTR gating is linked to ATP binding and dimerization of its two nucleotide binding domains (NBDs). Channel activation also requires phosphorylation of the R domain by poorly understood mechanisms. Unlike conventional ligand-gated chan...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2004
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20041220-01